Polynucleotide (PN) — Ingredients

Category: Ingredients

SKINROUTE ·

A polymer ingredient of chain-linked DNA fragments, characterized by a larger molecular weight than PDRN, used for skin hydration and barrier care.

What is Polynucleotide (PN)?

A polymer ingredient of chain-linked DNA fragments, characterized by a larger molecular weight than PDRN, used for skin hydration and barrier care.

Short for Polynucleotide, a polymer of long-linked nucleotides. It is distinguished from the smaller-molecular-weight PDRN and is a trending ingredient used for moisture retention and barrier care.

Key properties & actions

Polynucleotide (PN) is a high-molecular-weight DNA fragment composed of long chains of nucleotides and is distinguished from PDRN, which has a smaller molecular weight. Its larger molecular structure is known to attract moisture to the skin's surface and form a hydrating film, and it may help with moisture retention and barrier conditioning.

How to manage

It is best used in ampoule or cream topical formulations as part of the moisturizing step. When used as a topical cosmetic, it is most accurately understood as a surface-level hydrating and conditioning ingredient; its action differs from that of in-clinic injectables. If you are considering an in-clinic injectable, consulting a dermatologist at a medical institution is recommended.

Good to know alongside

Polynucleotide is frequently compared to PDRN and hyaluronic acid as a trending ingredient in hydration and barrier care, and the three are distinguished primarily by differences in molecular weight.

Everyday care tips

PN ampoules may feel slightly tacky, so dispensing a small amount and spreading it in a thin, even layer across the face before sealing with a moisturizing cream is advisable.

Manage Polynucleotide (PN) with SKINROUTE

  • Skin100 Analysis — Skin100 precision analysis — 100+ questionnaire items analyzed by AI into 8 core skin factors
  • AI Skin Consultation — AI skin consultation chat — ask questions about your skin in your language
  • AI Challenge — AI-personalized 4–20 week skincare challenge based on your analysis results

Frequently Asked Questions (FAQ)

What is Polynucleotide (PN)?
A polymer ingredient of chain-linked DNA fragments, characterized by a larger molecular weight than PDRN, used for skin hydration and barrier care. Short for Polynucleotide, a polymer of long-linked nucleotides. It is distinguished from the smaller-molecular-weight PDRN and is a trending ingredient used for moisture retention and barrier care.

Related Entries

Explore Other Categories

Sources & References

Medical Disclaimer

SKINROUTE is not a medical device or healthcare provider. All content is general skincare information for reference only. If you have concerns about your skin, please consult a board-certified dermatologist.